{"id":1858,"date":"2025-02-08T23:25:13","date_gmt":"2025-02-08T23:25:13","guid":{"rendered":"https:\/\/info-eforie.ro\/index.php\/2025\/02\/08\/cum-poate-creste-rata-de-succes-a-transplanturilor-pulmonare-rezultatele-neasteptate-ale-celui-mai-recent-studiu\/"},"modified":"2025-02-08T23:25:13","modified_gmt":"2025-02-08T23:25:13","slug":"cum-poate-creste-rata-de-succes-a-transplanturilor-pulmonare-rezultatele-neasteptate-ale-celui-mai-recent-studiu","status":"publish","type":"post","link":"https:\/\/info-eforie.ro\/index.php\/2025\/02\/08\/cum-poate-creste-rata-de-succes-a-transplanturilor-pulmonare-rezultatele-neasteptate-ale-celui-mai-recent-studiu\/","title":{"rendered":"Cum poate cre\u0219te rata de succes a transplanturilor pulmonare. Rezultatele nea\u0219teptate ale celui mai recent studiu"},"content":{"rendered":"<div>\n<p>Un studiu recent relev\u0103 c\u0103\u00a0infec\u021bia cu\u00a0Pseudomonas\u00a0aeruginosa\u00a0poate declan\u0219a respingerea transplantului pulmonar, dar cercet\u0103torii au identificat \u0219i o poten\u021bial\u0103 solu\u021bie pentru a preveni acest fenomen.<\/p>\n<div><picture loading=\"eager\" width=\"1400\" height=\"750\" alt=\"Leg\u0103tur\u0103 dintre transplantul de pl\u0103m\u00e2ni \u0219i o infec\u021bie bacteriana. Foto: Shutterstock\"><source type=\"image\/webp\"  media=\"(min-width: 1400px)\"><source type=\"image\/webp\"  media=\"(min-width: 1000px)\"><source type=\"image\/webp\"  media=\"(min-width: 700px)\"><source type=\"image\/jpeg\"  media=\"(min-width: 1400px)\"><source type=\"image\/jpeg\"  media=\"(min-width: 1000px)\"><source type=\"image\/jpeg\"  media=\"(min-width: 700px)\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/cdn.adh.reperio.news\/image-5\/58a514c3-ab7a-45c9-a523-b5dd27d1857b\/index.jpeg?p=a%3D1%26co%3D1.05%26w%3D700%26h%3D750%26r%3Dcontain%26f%3Dwebp\" alt=\"Leg\u0103tur\u0103 dintre transplantul de pl\u0103m\u00e2ni \u0219i o infec\u021bie bacteriana. Foto: Shutterstock\" width=\"1400\" height=\"750\" loading=\"eager\"><\/picture>\n<p>Leg\u0103tur\u0103 dintre transplantul de pl\u0103m\u00e2ni \u0219i o infec\u021bie bacteriana. Foto: Shutterstock<\/p>\n<\/div>\n<p>Potrivit publica\u021biei\u00a0<a href=\"https:\/\/medicalxpress.com\/news\/2025-02-common-bacterial-infection-trigger-lung.html\" rel=\"nofollow\">Medicalxpress<\/a>,\u00a0un grup de cercet\u0103tori americani\u00a0a descoperit o leg\u0103tur\u0103 \u00eentre infec\u021bia cu\u00a0Pseudomonas\u00a0aeruginosa\u00a0\u0219i respingerea pl\u0103m\u00e2nilor\u00a0transplanta\u021bi. Studiul lor, publicat \u00een prestigiosul jurnal\u00a0<a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adp1349\" rel=\"nofollow\">Science\u00a0Translational\u00a0Medicine<\/a>, analizeaz\u0103 istoricul medical al pacien\u021bilor care au suferit transplant pulmonar \u0219i eviden\u021biaz\u0103 o corela\u021bie nea\u0219teptat\u0103 \u00eentre prezen\u021ba bacteriei \u0219i\u00a0respingerea transplantului.<\/p>\n<p>Pentru pacien\u021bii cu afec\u021biuni pulmonare severe, un transplant de pl\u0103m\u00e2ni reprezint\u0103 adesea ultima speran\u021b\u0103 de a-\u0219i rec\u0103p\u0103ta o calitate a vie\u021bii \u00eembun\u0103t\u0103\u021bit\u0103. Totu\u0219i, chiar \u0219i dup\u0103 transplant, teama ca organismul s\u0103 resping\u0103 noul organ persist\u0103, iar ratele de succes ale transplanturilor pulmonare r\u0103m\u00e2n printre cele mai sc\u0103zute comparativ cu alte tipuri de transplanturi.\u00a0<\/p>\n<p>Ini\u021bial, cercet\u0103torii au analizat dosarele medicale ale pacien\u021bilor care au primit un transplant pulmonar, c\u0103ut\u00e2nd cazuri \u00een care infec\u021bia cu\u00a0Pseudomonas\u00a0aeruginosa\u00a0\u0219i\u00a0respingerea transplantului au ap\u0103rut simultan.\u00a0Rezultatele au ar\u0103tat c\u0103 frecven\u021ba respingerii era mai mare dec\u00e2t se anticipase, motiv pentru care echipa a decis s\u0103 efectueze \u0219i experimente pe \u0219oareci de laborator.<\/p>\n<p>\u00cen experimentele efectuate, \u0219oarecii, care erau s\u0103n\u0103to\u0219i, au fost infecta\u021bi cu\u00a0Pseudomonas\u00a0aeruginosa\u00a0\u0219i ulterior li s-au transplantat pl\u0103m\u00e2nii de la al\u021bi \u0219oareci. Monitorizarea evolu\u021biei lor a relevat faptul c\u0103 bacteria se r\u0103sp\u00e2ndea \u00een \u021besuturile limfoide, unde distrugea celulele CD4+. Aceast\u0103 distrugere a determinat o cre\u0219tere a num\u0103rului de celule B care exprimau proteina CXCR3. Celulele B, sensibilizate la antigenele din pl\u0103m\u00e2nii dona\u021bi, au \u00eenceput s\u0103 produc\u0103 anticorpi specifici donatorului, declan\u0219\u00e2nd astfel mecanismul de respingere a organului transplantat.<\/p>\n<p>Un alt aspect important al studiului a fost descoperirea c\u0103 administrarea unor medicamente ce blocheaz\u0103 exprimarea proteinei CXCR3 la celulele B poate inhiba mecanismul de respingere. \u00cen experimentele cu \u0219oareci, tratamentul a permis men\u021binerea\u00a0func\u021biei noilor pl\u0103m\u00e2ni, suger\u00e2nd o posibil\u0103 abordare terapeutic\u0103 pentru pacien\u021bii transplantului pulmonar.<\/p>\n<p>Descoperirea leg\u0103turii dintre infec\u021bia cu\u00a0Pseudomonas\u00a0aeruginosa\u00a0\u0219i respingerea transplantului pulmonar deschide noi direc\u021bii pentru prevenirea complica\u021biilor post-transplant. Dac\u0103 rezultatele experimentale vor fi confirmate \u0219i \u00een studii clinice pe oameni, blocarea expresiei proteinei CXCR3 ar putea deveni o strategie valoroas\u0103 \u00een managementul pacien\u021bilor cu transplant pulmonar.<\/p>\n<\/p><\/div>\n<div>\n<p><strong>Cite\u0219te mai multe despre: <\/strong><br \/>\n        <a href=\"http:\/\/adevarul.ro\/tag\/studiu\" title=\"Ultimele \u0219tiri despre studiu\">studiu<\/a><\/p>\n<\/div>\n<p><a href=\"https:\/\/adevarul.ro\/stiri-interne\/sanatate\/cum-poate-creste-rata-de-succes-a-transplanturilor-2420499.html\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un studiu recent relev\u0103 c\u0103\u00a0infec\u021bia cu\u00a0Pseudomonas\u00a0aeruginosa\u00a0poate declan\u0219a respingerea transplantului pulmonar, dar cercet\u0103torii au identificat \u0219i o poten\u021bial\u0103 solu\u021bie pentru a preveni acest fenomen. Leg\u0103tur\u0103 dintre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1859,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[6],"tags":[],"class_list":["post-1858","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-popular"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/posts\/1858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/comments?post=1858"}],"version-history":[{"count":0,"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/posts\/1858\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/media\/1859"}],"wp:attachment":[{"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/media?parent=1858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/categories?post=1858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/info-eforie.ro\/index.php\/wp-json\/wp\/v2\/tags?post=1858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}